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Gurung, P, Yetiskul, E, Jialal, I

In particular, the animal study 7 in which pharmacological inhibition of GPx activity significantly reduced brain infarct damage suggested that under reduced oxygen supply, H 2 O 2 may exert either physiological or protective roles in the brain through its metabolic degradation to oxygen by catalase compensating for the lack of oxygen that occurs in the tissue after an ischemic event

PMID: 27356237

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According to these results, UMB might be applied as a possible adjuvant treatment in MTX chemotherapy regimens to overcome intestinal injury caused by MTX through the regulation of oxidative stress and inflammatory cascades